DSIP
Mechanism.
DSIP was discovered in the 1970s as a substance that seemed to bring on deep, slow-wave sleep in animals. Over the following decade researchers reported all sorts of effects — on sleep, stress hormones, pain, and circadian rhythm — but the results never gelled into something reliable, and it showed a strange dose-response where higher doses didn't work better. Since then it has largely been abandoned, with essentially no modern controlled trials backing it as a sleep aid. Its tendency to touch many unrelated systems makes it hard to say what it actually does in people.
A 1970s 'sleep peptide' that never lived up to its name in controlled testing — an interesting historical lead that quietly faded rather than proving itself.
How it's taken.
Community-reported · unregulatedValues below reflect commonly reported community protocols for DSIP. These are anecdotal and unregulated — not clinically validated and not a recommendation. Provided for educational purposes only — this is not medical advice and not instructions for self-administration. Consult your healthcare provider before making any health decision.
Use the free peptide calculator for dilution, unit conversion, and injection volume.
Side effects, rare serious events, who shouldn't.
How strong is the evidence?
Every study we cite.
We list each study with its methodology, funding source, and our quality grade. Flagged studies aren't dismissed — they're tagged so you can weigh them.
What didn't work, and where the evidence is thin.
Every publication is incentivized to tell you a peptide works. We catalogue the null results, failed trials, and mechanism limits we found in the same literature — so you can weigh them against the upside, with your provider.
Where it's available, at what price.
Questions to bring.
Every citation, numbered.
Citation list. For our editorial read of each study — including bias flags and quality grades — see the Research log above.
- 01.
- 02. PubMed. DSIP historical sleep-peptide literature