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A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques.

Bioactive materials · 2026

Despite advances in therapies for atherosclerosis, the limited efficacy in reversing vulnerable atherosclerotic plaques remains a significant challenge in translational cardiovascular research. We developed OPN-HMCN@MLT, a targeted nanoplatform combining melatonin (MLT) with an osteopontin (OPN)-binding peptide and hyaluronic acid-modified mesoporous carbon. By exploiting the acidic, HAase-overexpressing, and OPN-enriched microenvironment of vulnerable plaques, this system enables cascade-responsive drug release triggered sequentially by OPN recognition, HA degradation, and acidic pH. This sys

A Pilot Study to Estimate Early Clinical Efficacy Signals of a Glucagon-like Peptide 1 Receptor Agonist (GLP-1RA) Administration in Conjunction With Levonorgestrel Intrauterine Device (LNG-IUD) in Obese Patients With Endometrioid Intraepithelial Neoplasia

2026-04-07

This study will explore the use of glucagon-like peptide 1 receptor agonist (GLP-1RA) used concurrently with levonorgestrel intrauterine device in patients with poor surgical candidacy for a hysterectomy or patients who are pursuing fertility sparing. GLP-1RA are a class of medications that mimic the natural hormone glucagon-like peptide-1. These medications trigger the pancreas to release insulin which can help lower blood sugar levels and delay gastric emptying. The recent FDA approval of GLP-1RAs has changed the landscape for pharmacotherapy for weight loss. These hormone-based obesity medi

Comparative Effectiveness of Tirzepatide Versus Dulaglutide or Semaglutide on Major Cardiovascular Events in Type 2 Diabetes and Cardiovascular Disease: Insights From Two Target-Trial Emulations.

Diabetes care · 2026

To evaluate the comparative effectiveness of dulaglutide or semaglutide versus tirzepatide on cardiovascular outcomes in adults with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD).

Copper peptide activated cascade catalysis for glucose regulation and hypoxia reversing in infected diabetic wound healing.

Materials today. Bio · 2026

Starvation therapy has emerged as a promising strategy in diabetic wounds treating by regulating glucose level to deplete microbial nutrients without inducing antimicrobial resistance. However, this process consumes large amounts of oxygen, exacerbating wound hypoxia and compromising therapeutic efficacy. In this study, we designed a GOX-loaded hydrogel incorporated with copper peptide (GHK-Cu) to construct a copper peptide-activated cascade catalysis system for concurrent glucose regulation and hypoxia reversing. GOX initiates the cascade by catalyzing glucose oxidation, which reduces local h

Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress

2026-01-26

The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemicals produced by the body change under conditions of higher versus lower heat stress? * What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?

Dose-dependent modulation of mitochondrial physiology and nutrient secretion in Sertoli cells by l-carnitine.

Toxicology and applied pharmacology · 2026

l-Carnitine is a ubiquitous quaternary amine, essential for the mitochondrial β-oxidation of long-chain fatty acids, and a dietary supplement widely consumed by athletes due to its purported ergogenic and recovery-enhancing properties. Beyond its metabolic role in muscle tissue, l-Carnitine is highly concentrated in the male reproductive tract, suggesting a critical function in spermatogenesis. In the testis, Sertoli cells (SCs) act as essential "nurse cells," providing structural, nutritional, and immunomodulatory support to developing germ cells. This study elucidates the effects of l-Carnit

Effect of Mazdutide on Coronary Plaque Progression in Patients With Coronary Atherosclerosis and Overweight or Obesity: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial

2026-05-25

This multicenter, randomized, double-blind, placebo-controlled trial aims to evaluate the effect of mazdutide, a dual GLP-1/GCG receptor agonist, on coronary plaque progression assessed by coronary computed tomography angiography (CCTA) in patients with coronary atherosclerosis and overweight or obesity. The primary endpoint is the change in total non-calcified plaque volume (NCPV) from baseline to week 52. Secondary endpoints include changes in pericoronary adipose tissue inflammation (fat attenuation index, FAI), plaque composition, metabolic parameters, inflammatory biomarkers, and clinical

Efficacy and Safety of Cagrilintide and Cagrisema Versus Semaglutide as Anti-Obesity Medications: A Systematic Review, Meta-Analysis and Meta-Regression.

Diabetes, obesity & metabolism · 2026

Obesity is a complex chronic disease requiring effective long-term management. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of cagrisema and cagrilintide monotherapy compared with semaglutide in individuals with obesity.

Efficacy and Safety of the Dual Glucagon-Like Peptide-1 and Glucagon Receptor Agonist Mazdutide in Predominantly Chinese Adults With Obesity and/or Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Diabetes, obesity & metabolism · 2026

To assess the effects of mazdutide on body weight, HbA1c, metabolic outcomes, and adverse events in adults with overweight/obesity and/or type 2 diabetes (T2D).

Elamipretide in pediatric Barth syndrome: from heart failure to school return.

Orphanet journal of rare diseases · 2026

Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder characterized by cardiomyopathy, neutropenia, and skeletal myopathy. Elamipretide is a mitochondria-targeting peptide that stabilizes cardiolipin and improves mitochondrial function. While use of this treatment in infants with BTHS has been reported in the United States, no cases have been described outside the US or in older children.

Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability.

Nature cell biology · 2026

Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have broad therapeutic appeal. Here we report a senolytic screen of a library of 10,480 electrophilic compounds. Among 38 identified hits, we found a subset of chloroacetamides with broad senolytic activity. Activity-based protein profiling, coupled with functional assays, identified the glutathione peroxidase GPX4 as a target. We show that senescent cells are primed for ferroptosis, displaying high levels of oxidative stress and intracellular Fe

Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential.

Archives of pharmacal research · 2026

Skeletal muscle, once regarded solely as a contractile tissue, is now recognized as a dynamic endocrine organ that secretes exercise-induced myokines-bioactive peptides with autocrine, paracrine, and endocrine functions. These myokines coordinate systemic energy homeostasis by regulating glucose and lipid metabolism, mitochondrial function, inflammation, and interorgan communication. Building on our previous review published in 2018, this review synthesizes major advances in exercise-induced myokines within an evidence-based framework considering mechanistic support and translational relevance

GLP-1 Agonists in Adolescent Obesity: A Narrative Review of Single, Dual, and Triple Agonists.

Diabetes, metabolic syndrome and obesity : targets and therapy · 2026

Adolescent obesity is an escalating global health concern associated with increased risks of cardiovascular disease, type 2 diabetes mellitus, and long-term metabolic complications. Although lifestyle interventions remain first-line therapy, their limited long-term effectiveness has led to increasing interest in pharmacological approaches. This narrative review evaluates the mechanisms, clinical efficacy, and safety of glucagon-like peptie-1 (GLP-1) receptor agonists, as well as emerging dual and triple incretin-based therapies, in the management of adolescent obesity. A literature search was

Glutathione metabolic reprogramming by ferroptosis inducers potentiates cuproptosis and antitumor immunity in osteosarcoma.

International immunopharmacology · 2026

Osteosarcoma (OS) is a common malignant bone tumor that predominantly affects adolescents and is highly invasive and metastatic. Current treatment options have suboptimal efficacy, highlighting the urgent need for novel therapeutic strategies. Cuproptosis, a recently discovered form of copper-dependent cell death, has demonstrated potential in cancer therapy, yet its clinical application remains to be fully explored. Ferroptosis, another iron-dependent programmed cell death pathway, has shown efficacy against certain cancers through its induction. Recent studies suggest that ferroptosis induce

HELLS inhibits autophagy‑dependent ferroptosis in nasopharyngeal carcinoma by modulating the Nrf2/HO‑1/GPX4 pathway.

International journal of molecular medicine · 2026

The present study aimed to elucidate the role of lymphoid‑specific helicase (HELLS) in autophagy‑dependent ferroptosis in nasopharyngeal carcinoma (NPC) cells and associated mechanisms. Bioinformatics analyses were conducted to identify the key gene. Gene knockout was accomplished through short‑hairpin RNA transfection. Reverse transcription‑quantitative polymerase chain reaction was conducted to evaluate mRNA expression, whereas protein expression was assessed through immunohistochemistry and western blotting. Furthermore, cell proliferation, migration, invasion and apoptosis were investigate

Hepatoprotective effects of epigallocatechin gallate and glutathione on aflatoxin B1-induced subacute liver injury in ducklings.

Poultry science · 2026

Aflatoxin B

Identifying Therapeutic Mechanisms for Incretin-Based Treatment in Obesity-Related Heart Failure With Preserved Ejection Fraction (HFpEF)

2026-06

The central hypothesis to be tested is that patients with obesity and heart failure with preserved ejection fraction (HFpEF) prescribed tirzepatide will demonstrate reductions in measured plasma volume. In conjunction with state-of-the-art body composition analysis and measures of adipokines, this will establish an important mechanism of clinical benefit and inform disease pathophysiology. To accomplish this, this study will perform a 15-month prospective cohort study in 50 patients with obesity and HFpEF who clinically qualify for treatment with tirzepatide. The investigators will serially me

Implementing a point-of-care test for β-human chorionic gonadotropin testing within an abortion service.

BMJ sexual & reproductive health · 2026

Interactive impacts of social deprivation and intranasal oxytocin administration on oxytocin receptor density in prairie vole brains.

Frontiers in behavioral neuroscience · 2026

Early-life social experiences have a profound impact on the development of the brain and behavior. Previous work has shown that prairie voles (

Intranasal oxytocin for alcohol use disorder: A systematic review and multilevel, bayesian, and variance meta-analyses of randomized clinical trial data.

Psychoneuroendocrinology · 2026

Intranasal oxytocin (OT) has been proposed as a promising adjunctive treatment for Alcohol Use Disorder (AUD), yet randomized controlled trials (RCTs) have yielded mixed and inconclusive findings. To clarify its therapeutic potential, we conducted a comprehensive meta-analysis using frequentist, Bayesian, and variability-based approaches.

Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia

2026-06-20

More than 15 million family caregivers provide support for individuals with Alzheimer's disease (AD) or related dementias. This number is expected to grow with the increasing population of persons with dementia (PWD). Stress in caregivers to older adults with chronic diseases is already a significant public health issue because it is associated with multiple negative physical and mental health outcomes for the caregiver (e.g., depression, cardiovascular disease) and can negatively impact the health of the PWD as well. Importantly, stress levels are even higher in female than male caregivers an

Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors Agonists

2026-04-01

Treatment with semaglutide slows down gastric emptying , food remains in the stomach for a longer period of time. This slowing has important implications for anesthesia management. At present, we do not know the optimal duration for discontinuing this medication before surgery and anesthesia to ensure an empty stomach. This is an observational research project, conducted exclusively at the Geneva University Hospitals (HUG). To answer the research question, participation of 38 individuals will be required. The duration of participation for each person is 7 days. To recruit the necessary numbe

Ixekizumab With or Without Tirzepatide in Adults With Psoriasis and Overweight or Obesity: A Phase 3b Randomized Clinical Trial.

JAMA dermatology · 2026

Overweight and obesity affect 60% to 78% of patients with psoriasis, affecting disease severity, treatment response, and clinical outcomes. However, no large, randomized, active-controlled clinical trial has evaluated a treatment strategy that addresses both diseases simultaneously.

Melatonin Targets Mitochondrial Redox Homeostasis: Optimizing the Intracellular Microenvironment.

International journal of molecular sciences · 2026

The discovery of melatonin as a multifunctional free radical scavenger and its possible synthesis in the mitochondrial matrix of peripheral eukaryotic somatic cells highlights a critical new perspective on the importance of this indole. Experimental evidence supporting these findings is substantial, but there are still lingering questions whether melatonin is a direct radical scavenger in vivo and whether it is synthesized in the mitochondrial matrix. We systematically analyze the innovative experimental approaches that support melatonin's radical scavenging actions and assess the compelling d

Melatonin Versus Solifenacin Versus Their Combination for Improving Double-J Ureteral Stent-Related Symptoms and Quality of Life: A Prospective Randomized Study

2026-05-07

Double-J ureteral stents are commonly inserted after ureteroscopy, but they may cause bothersome urinary symptoms, pain, sleep disturbance, and reduced quality of life. This prospective randomized assessor-blinded three-arm clinical trial will compare oral solifenacin, oral melatonin, and their combination for improving ureteral stent-related symptoms in adult patients after unilateral ureteroscopic lithotripsy with insertion of a unilateral Double-J ureteral stent. Participants will be randomized to receive solifenacin 5 mg once daily, melatonin 3 mg once nightly, or combined solifenacin 5

Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells.

Inflammation and regeneration · 2026

Mesenchymal stromal cells (MSCs) possess therapeutic potential largely reliant on intact mitochondrial function to maintain reparative function. However, obesity compromises MSC metabolism and reparative capacity. MOTS-c, a mitochondria-derived peptide, is known to regulate cellular metabolism, but its role in human MSC biology remains unclear. We hypothesized that restoring MOTS-c signaling rescues the impaired functionality of adipose-derived MSCs from individuals with obesity.

Myostatin Signaling in Skeletal Muscle: Implications for Athletic Performance.

Comprehensive Physiology · 2026

Myostatin, encoded by the MSTN gene, is a critical negative regulator of skeletal muscle growth and plays a central role in maintaining muscle homeostasis. It regulates satellite cell proliferation, differentiation, and protein synthesis through both Smad-dependent and non-Smad signaling pathways. Overexpression of myostatin promotes muscle atrophy and delays recovery, whereas reduced myostatin activity enhances protein synthesis and muscle regeneration, primarily by modulating the IGF-1/Akt/mTOR signaling pathway. Modulation of myostatin has been associated with improved metabolic function, i

Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis.

Drug design, development and therapy · 2026

Rosacea is a chronic inflammatory skin disease with a global prevalence of approximately 5.1%. Existing evidence suggests that its pathogenesis may be associated with dysregulation of the neuro-hormone-immune network within the skin-gut-brain axis framework. This review summarizes the potential roles of stress hormones, sex hormones, and insulin-like growth factor-1 in the four major subtypes. In erythematotelangiectatic rosacea, glucocorticoid resistance within keratinocytes may induce CCL20-driven Th17 inflammation, while catecholamines released by sympathetic nerves are associated with neur

On Superpowers, Oxytocin, and Sciences-Reflections on a Challenging Field.

Journal of integrative and complementary medicine · 2026

Oxytocin and RAGE signaling at the intersection of social neurodevelopment and inflammation.

Journal of translational medicine · 2026

Autism spectrum disorder (ASD) prevalence continues to rise despite no recent changes to screening or diagnostic criteria. A complete understanding of the pathophysiology of ASD remains elusive. Gestational and postnatal inflammation correlate strongly with ASD prevalence, which is supported by maternal immune activation prevalence studies, maternal immunoglobulin found in fetal brains with ASD and altered T-cell populations in ASD children. Elevated TNF-α, interleukins, nuclear factors, and toll-like receptor levels reported in subgroups of ASD children provide evidence of a chronic inflammat

Oxytocin release patterns and effects, with a focus on touch, social interaction, and closeness.

Frontiers in psychology · 2026

Clinical evidence indicates that tactile stimulation of the skin, such as stroking or gentle touch, elicits a range of beneficial physiological and psychological responses, such as increased social interaction, wellbeing, calm, restorative and growth promoting effects, as well as reduced fear, pain, and stress levels. These effects are mediated by activation of cutaneous sensory nerves, which relay signals to central regulatory systems. During this process, several neuropeptides and hormones are released, one of which is oxytocin produced in the supraoptic (SON) and paraventricular (PVN) nucle

Photoperiod as a neuroendocrine regulator: A review on pineal-melatonin signaling and physiological plasticity in poultry.

Poultry science · 2026

Photoperiod, the cyclical exposure to light and darkness, is a master regulator of neuroendocrine function in poultry, primarily via the pineal-melatonin axis. The pineal gland translates photic cues into rhythmic melatonin secretion, which synchronizes circadian and seasonal biological processes, linking environmental signals to systemic homeostasis. This review systematically explores pineal-melatonin signaling network, highlighting its pivotal role in regulating reproduction, growth, metabolic homeostasis, immune competence, and stress resilience. Mechanistically, melatonin modulates core c

Pituitary Axis Impacts and Effectiveness of Clomiphene and Human Chorionic Gonadotropin in Treating Hypogonadism: Cohort Study.

The world journal of men's health · 2026

Men with testosterone deficiency (TD) aiming to preserve testicular function can be treated with strategies including testosterone replacement therapy (TRT) combined with human chorionic gonadotropin (hCG) or clomiphene citrate (CC), or CC monotherapy. Evidence regarding these strategies on the pituitary axis and quality of life is limited.

Redox protection by bacterial glutathione peroxidase drives virulence in

Redox report : communications in free radical research · 2026

Retatrutide: Triple acting jab for type 2 diabetes lowers blood sugar and boosts weight loss, trial reports.

BMJ (Clinical research ed.) · 2026

Sensory Neuroimmunology: Bidirectional Neuro-Immune Circuits Governing Pain, Itch, Inflammation, and Host Defense at Barrier Surfaces.

Biology · 2026

Sensory neurons at barrier tissues were once seen as passive detectors of environmental stimuli. However, in the last five years, increasing evidence has challenged this view, redefining these cells as active immune sentinels that directly affect tissue immunity in the skin, lungs, and gastrointestinal tract. Nociceptors and pruriceptors express various immune-sensing receptors, including Toll-like receptors, cytokine receptors, and alarmin sensors, which allow them to directly detect pathogens, allergens, and tissue damage. When activated, sensory neurons quickly release neuropeptides such as

Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH): a clinical trial protocol.

BMJ open · 2026

The Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH) study is a randomised controlled trial with the overall goal of examining the combined effect of exercise and the growth hormone-releasing hormone analogue tesamorelin on physical function.

Thiol depletion and disruption of proteostasis contribute to the phytotoxicity of juglone

biorxiv preprint · 2026-04-13

O_LIJuglone is the phytotoxic 1,4-naphthoquinone responsible for the allelopathic effects of black walnut (Juglans nigra), yet how plants perceive and respond to juglone remain poorly understood. C_LIO_LIWe conducted transcriptome profiling of rosettes and roots of Arabidopsis thaliana exposed to juglone from 30 min to 5 d, along with targeted metabolic profiling, biochemical assays, and untargeted proteomics to gain a systems-level understanding of how plants respond to juglone and to test hypotheses underlying its phytotoxicity. C_LIO_LIJuglone exposure induced expression of genes involved i

Tirzepatide and the Cardiovascular Continuum: Metabolic, Cardiorenal and Heart Failure Evidence.

Clinical Medicine Insights. Cardiology · 2026

Tirzepatide is a first-in-class, once-weekly dual GIP and GLP-1 receptor agonist approved for type 2 diabetes and obesity. Given the tight link between hyperglycemia, adiposity, and cardiovascular disease, tirzepatide has rapidly gained interest as a broader cardiometabolic intervention. This narrative review summarizes mechanistic rationale and clinical evidence on cardiovascular risk-factor modification, cardiorenal signals, and outcome data. Across the SURPASS program in type 2 diabetes, tirzepatide produces large, dose-dependent reductions in HbA1c and substantial weight loss, with consist

Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring.

Nature communications · 2026

Assisted reproductive technology influences the epigenetic landscape of offspring, but whether trigger-day pharmacotherapy affects epigenetics and neurodevelopment remains unclear. In a prospective birth cohort of 365 families, higher trigger-day human chorionic gonadotropin dose associates with reduced global DNA methylation in peripheral blood from offspring conceived assisted reproduction compared with naturally conceived children. In a cohort of 1333 singleton offspring, higher maternal human chorionic gonadotropin dose associates with increased risk of suboptimal neurodevelopment. In mice

Effect of L-carnitine on Disease Activity in Patients With Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial

2025-06-28

The purpose of this study is to evaluate the effects of L-carnitine on symptomatic improvement, oxidative stress, and inflammation in mild to moderate knee osteoarthritis patients.

Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial.

The lancet. Diabetes & endocrinology · 2025

BACKGROUND Retatrutide, a glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, and glucagon receptor agonist, has demonstrated robust glucose and bodyweight reductions in participants with type 2 diabetes. This substudy assessed percent change from baseline to week 36 in total body fat mass versus placebo and dulaglutide. METHODS This phase 2, double-blind, parallel-group, placebo-controlled, randomised controlled trial was done in 42 medical centres in the USA. Eligible participants were adults aged 18-75 years with type 2 diabetes, HbA1c of 7·0-10·5%, stable bodyweight, a

Efficacy and Safety of GLP‐1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian NMA

Obesity · 2025

Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials

Baylor University Medical Center Proceedings · 2025

Abstract Background Retatrutide is a novel triple agonist targeting the receptors of glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon. We sought to assess the efficacy and safety of retatrutide in obese patients with or without diabetes. Methods PubMed, Scopus, Web of Science, and Cochrane databases were searched from inception until May 2024. Eligible studies comprised randomized controlled trials that compared retatrutide with placebo in obese patients. We excluded studies on healthy populations, non-English texts, single-arm studies, animal studies, and ab

Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP

Advanced Science · 2025

Triple‐negative breast cancer (TNBC) in obese patients remains challenging. Recent studies have linked obesity to an increased risk of TNBC and malignancies. Through multiomic analysis and experimental validation, a dysfunctional Eukaryotic Translation Initiation Factor 3 Subunit H (EIF3H)/Yes‐associated protein (YAP) proteolytic axis is identified as a pivotal junction mediating the interplay between cancer‐associated adipocytes and the response to anti‐cancer drugs in TNBC. Mechanistically, cancer‐associated adipocytes drive metabolic reprogramming resulting in an upregulated hexosamine bios

Pupillometry in DSWPD Type 1 and Type 2

2025-09-01

The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims to answer is: Are there differences in the light response in patients with delayed sleep-wake phase disorder? Does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder? Participants will complete activity and melatonin testing at home to determine their circ

Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials

Diabetes, Obesity & Metabolism · 2025

Retatrutide, a novel synthetic molecule, is a triple agonist activating the glucose‐dependent insulinotropic polypeptide, glucagon‐like peptide‐1 and glucagon receptors. The TRIUMPH clinical development program evaluates its safety and efficacy concurrently for the treatment of obesity and two related complications—obstructive sleep apnea (OSA) and knee osteoarthritis (OA). A novel basket trial design simultaneously evaluates retatrutide treatment across these multiple adiposity‐related disease states.

The Effect of Retatrutide on Kidney Parameters in Participants With Type 2 Diabetes Mellitus and/or Obesity

Kidney International Reports · 2025

Introduction Obesity and type 2 diabetes mellitus (T2D) increase the risk of kidney disease. This study assessed changes in kidney parameters with retatrutide, an agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors. Methods A post hoc analysis of 2 retatrutide studies (dose range: 0.5–12 mg) was performed in participants (estimated glomerular filtration rate [eGFR] ≥ 45 ml/min per 1.73 m2) with T2D (n = 281) and with overweight or obesity without T2D (n = 338). Both studies were placebo-controlled; the T2D study included du

The Evaluation of the Effect of Music That the Individuals With Moderate Dental Anxiety Have Started Listening to on Their Anxiety Levels While Waiting for Restorative Dental Treatments in the Patient Waiting Room

2025-04-17

It is aimed to evaluate the effect of music listened to in the waiting room on patients with moderate dental anxiety during the restoration of posterior occlusal dental caries on vital signs, cortisol and oxytocin levels of the participants.

The Long COVID Treatment Trial

2025-10-30

The goal of this study is to determine whether a medicine called tirzepatide, also called Zepbound, can reduce symptoms of Long COVID. A randomized control trial will allow us to measure the effect of the treatment by having half of the participants take the medication and half take a placebo that has no medication. Participants will take the medication (or placebo) they are given and complete study surveys for 12 months. All of the study tasks are done remotely from the comfort of a participants home.